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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ECH1
All Species:
13.64
Human Site:
S22
Identified Species:
33.33
UniProt:
Q13011
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13011
NP_001389.2
328
35816
S22
L
T
R
R
L
T
G
S
N
Y
P
G
L
S
I
Chimpanzee
Pan troglodytes
XP_001167817
328
35675
S22
L
T
R
R
L
T
G
S
N
Y
P
G
L
S
I
Rhesus Macaque
Macaca mulatta
XP_001084167
320
35031
S22
L
S
R
R
L
T
A
S
N
Y
S
G
L
S
I
Dog
Lupus familis
XP_533678
328
35870
P22
L
M
R
R
L
V
A
P
T
P
Q
G
L
S
L
Cat
Felis silvestris
Mouse
Mus musculus
O35459
327
36100
T22
L
M
Q
Q
L
R
G
T
S
Q
L
Y
F
N
I
Rat
Rattus norvegicus
Q62651
327
36153
T22
L
M
Q
Q
L
R
G
T
R
Q
L
Y
F
N
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086341
285
31456
N22
L
K
V
A
L
V
P
N
H
I
I
H
V
E
I
Zebra Danio
Brachydanio rerio
NP_001006068
308
33755
V22
F
V
P
F
L
N
A
V
R
G
M
S
S
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608375
312
33800
L22
K
P
T
A
I
G
S
L
K
M
Q
R
N
L
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784041
285
31394
F22
A
V
T
S
P
Q
E
F
I
Y
K
V
E
V
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.1
92.9
79.8
N.A.
74
75.3
N.A.
N.A.
N.A.
62.2
62.5
N.A.
48.1
N.A.
N.A.
51.2
Protein Similarity:
100
99.3
95.7
88.7
N.A.
87.8
87.8
N.A.
N.A.
N.A.
73.1
75
N.A.
65.5
N.A.
N.A.
65.8
P-Site Identity:
100
100
80
46.6
N.A.
26.6
20
N.A.
N.A.
N.A.
20
13.3
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
86.6
53.3
N.A.
60
53.3
N.A.
N.A.
N.A.
40
13.3
N.A.
6.6
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
20
0
0
30
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
0
10
10
0
% E
% Phe:
10
0
0
10
0
0
0
10
0
0
0
0
20
0
0
% F
% Gly:
0
0
0
0
0
10
40
0
0
10
0
40
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
10
10
10
0
0
0
50
% I
% Lys:
10
10
0
0
0
0
0
0
10
0
10
0
0
0
0
% K
% Leu:
70
0
0
0
80
0
0
10
0
0
20
0
40
10
10
% L
% Met:
0
30
0
0
0
0
0
0
0
10
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
10
30
0
0
0
10
20
10
% N
% Pro:
0
10
10
0
10
0
10
10
0
10
20
0
0
0
0
% P
% Gln:
0
0
20
20
0
10
0
0
0
20
20
0
0
0
0
% Q
% Arg:
0
0
40
40
0
20
0
0
20
0
0
10
0
0
0
% R
% Ser:
0
10
0
10
0
0
10
30
10
0
10
10
10
50
10
% S
% Thr:
0
20
20
0
0
30
0
20
10
0
0
0
0
0
0
% T
% Val:
0
20
10
0
0
20
0
10
0
0
0
10
10
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
40
0
20
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _